Background: Smoking in any form is a significant risk factor for developing cardiovascular diseases, chronic obstructive pulmonary disease, lung cancer, and other oxidative damage-induced diseases. The increasing global trend of E-cigarettes has led traditional smokers to perceive them as a safer option. background: Smoking in any form is a significant risk factor in developing cardiovascular diseases, chronic obstructive pulmonary disease, lung cancer, and oxidative damage. The global trend in E-cigarettes has led traditional smokers to believe it to be the safer option as it does not burn tobacco. Objectives: This study aimed to compare the levels of malondialdehyde (MDA) as a marker of oxidative damage and high-sensitivity C-reactive protein (hs-CRP) as a marker of inflammation between pure E-cigarette users and tobacco poly-users (smoking combinations of traditional products). Moreover, it also evaluated the influence of Body Mass Index, frequency, and duration of vaping/smoking on these biomarkers. objective: This study aimed to compare the differences in the levels of Malondialdehyde (MDA) as a marker of oxidative damage and high sensitivity C-reactive protein (hs-CRP) as a marker of inflammation between Pure E-cigarette users and polyusers who smoke combinations of different types of tobacco. Further, observe the influence of Body Mass Index, frequency, and duration of vaping/smoking on the biomarkers between the two groups. Materials and Methods: This analytical cross-sectional pilot study included 40 males aged 18-25 (20 pure E-cigarette users and 20 tobacco poly-users). MDA and hs-CRP were estimated on serum, and SPSS-Version 28.0.1.1 was used for data analysis. Mean hs-CRP and MDA levels for the two groups were compared using the Mann-Whitney-U test. method: This analytical cross-sectional pilot study was conducted with 40 males aged 18-25 (20 Pure E-cigarette users and 20 tobacco polyusers). MDA and hs-CRP were estimated on serum using standard procedures. SPSS Version 28.0.1.1 was used for data analysis. Mean hs-CRP and MDA levels were recorded for the two groups, and a comparison was made using the Mann-Whitney test. Results: Mean level of hs-CRP between the two groups was not significantly different. However, MDA levels were lower in pure E-cigarette users than in tobacco poly-users, especially among those with normal BMI and those who vaped/smoked more frequently and for a longer duration result: The mean level of hs-CRP between both groups was not significantly different; however, MDA levels were lower in Pure E-cigarette users than in tobacco polyusers, especially among those with normal BMI, those who vaped/smoked more frequently, and those who have been vaping/smoking for years. Conclusion: Oxidative damage was lesser for pure E-cigarette users and could potentially be the less harmful option than tobacco poly-use. However, E-cigarettes are not the safest substitute for conventional smoking as it causes a similar extent of risk for inflammation-related CVD. Findings need further exploration to study the long-term effects on a larger population group to draw definitive conclusions. conclusion: Oxidative damage was lesser for pure E-cigarette users and could potentially be the less harmful option than tobacco polyuse. However, E-cigarettes are not the safest substitute for conventional smoking as it causes a similar extent of risk for inflammation-related diseases. The only effort needed for a healthy lifestyle is to target smoking cessation rather than substitution.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.