Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or ‘MAM’). Moreover, several recent studies have shown that disturbances to ER–mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings.

Stray cats trapped in various areas of Basseterre, the capital of St Kitts in the West Indies, were tested for infection with feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) using commercial kits. Of 99 (51 male and 48 female) cats trapped in 2006/7, 15% (12 males and three females) were positive for FIV while none were positive for FeLV. Of 72 (41 males and 31 females) cats trapped in 2009, 14% (nine males and one female) were positive for FIV while none were positive for FeLV. Polymerase chain reaction analysis revealed DNA of Bartonella species in whole blood collected from 60/95 (63%) cats trapped in 2006/7. Sequencing of the 16S-23S rRNA gene intergenic transcribed spacer (ITS) region of a convenience sample of nine amplicons and the 11 isolates made from 43 blood samples which were cultured using Bartonella alpha Proteobacteria (BAPGM) enrichment medium revealed B henselae (14) and B clarridgeiae (six).

This article examines how Parisian university clerics responded to the city's communities of beguines (uncloistered religious women), highlighting in particular the ways in which clerics employed the term 'beguine' in sermons and preaching material from thirteenth-century Paris. Because the beguines were not hidden behind convent walls but were instead a visible presence in the city, they were often the focus of Parisian clerics' ideas about religious women. Sermons preached, composed, and copied in Paris reveal the process by which Parisian medieval thinkers constructed, although not always consciously, a negative meaning for the term 'beguine.' Always poorly defined, 'beguine' evoked a wide variety of meanings and associations for clerical observers in medieval Paris. The varied ideas about and images of the beguine allowed the Parisian intellectual elite to include these women in discussions of their own position in society as clerics in charge of the religious instruction of the laity. Clerics used the beguine as an example of the contemplative life, often comparing their own intellectual approaches to religious knowledge with the beguines' mystical knowledge. These positive comparisons, however, were joined by negative accusations when clerics expressed concern that the beguine thought too highly of her spiritual gifts.

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