In the last three years we observed a decrease of suicide attempts. We noticed that middle aged persons are the most frequent ones to attempt suicide. Depressive disorder is the most frequent pre-existing condition of suicide attempt. In order to prevent suicide attempts we must improve early detection of depressive disorder, as well as initial treatment.
<zakljucak> Poslednjih 50 godina postignuti su odlicni rezultati primenom elektrobioloske stimulacije osteogeneze. Precizno objasnjenje mehanizma dejstva EMP jos uvek nije dato, sto je jedan od razloga razlicitih pristupa i rezultata lecenja prema iskustvima klinicara i eksperimentnih studija. Uzimajuci u obzir studije sa dobrim bioloskim protokolom, preciznom dozimetrijom i definisanim eksperimentnim uslovima, stimulacija osteogeneze EMP ostace aktuelna i u buducnosti.
Introduction/Objective. The purpose of this study was to determine if patient-related factors, such as length of stay in hospital, and preoperative usage of walking aids, and geometrical factors, measured with antero-posterior radiographs of hip, affect the risk of hip dislocation after total hip arthroplasty. Methods. A total of 36 of 433 (8.31%) patients with hip dislocation were identified in the institutional registry during the two years period. The data for patients with and without hip dislocation were matched and compared. Results Hip dislocation more often occurred in patients who had used the walking aids before the operation compared to the ones who had not (p < 0.001). Also, the difference in the number of HD was noticed between the patients who stayed longer in the hospital after THA (p < 0.001) The patients with higher acetabular inclination angle (p < 0.005) and height of greater trochanter (p < 0.001) on radiographs had been more prone to hip dislocation. In addition to this, the "safe-zone" was not identified in our study (p > 0.005) Conclusion. Several factors, which influence hip dislocation, were identified in this study: patients characteristics and radiograph characteristics. Both groups of factors require attention and monitoring in future studies.
Neurogena disfunkcija mokraćne bešike nastala kao posledica oštećenja nervnih struktura kod spinalnih lezija predstavlja veliki problem za pacijenta, njegovu okolinu i zdravstvene radnike. Pravilno dijagnostikovanje neurogene disfunkcije mokraćne bešike omogućava primenu odgovarajućeg terapijskog i rehabilitacionog plana koji će omogućiti adekvatno pražnjenje i sprečavanje pojave komplikacija koje mogu ugroziti život pacijenta. U evoluciji povreda kičmene moždine mogu se razlikovati tri faze: 1) faza spinalnog šoka, 2) faza oporavka, 3) nalna faza. Posle spinalne traume m. bešika je zhvaćena najčešće na dva načina: 1) Spastična (re eksna) bešika nastaje zbog lezije iznad centra za mokrenje (segmenti S2-S4), 2) Flakcidna (atonična) neuropatska bešika nastaje kao posledica lezije u nivou centra za mokrenje (S2-S4) ili ispod njega, kao i lezije periferne inervacije bešike, 3) Sindrom autonomne disreeksije se razvija u bolesnika sa cervikalnim ili visokim torakalnim lezijama kičmene moždine, iznad 1 segmenta, 4) Neinhibirana neurogena bešika razvija se zbog inkompletnih lezija nervnih puteva u cerebralnom korteksu, piramidalnom putu ili u kičmenoj moždini oslabljena je cerebralna kontrola mokrenja. Dijagnoza neurogene disfunkcije se postavlja na osnovu urodinamskih ispitivanja, laboratorijskih pregleda urina i krvi, kao i rentgena, kompjuterizovane tomogra je i nuklearne magnetne rezonance kičmenog stuba. Pražnjenje mokraćne bešike moguće je intermitetnom kateterizacijom, Credeovim postupkom, suprapubičnom stimulacijom, elektrostimulacijom glatke muskulature mokraćne bešike i medikamentima. Neophodnost interdisciplinarnog pristupa lečenju ovih pacijenata ukazuje na svu težinu problema kod pacijenata sa povredama kičmenog stuba i posledične disfunkcije mokraćne bešike.Ključne reči: povreda kičmene moždine; neurogena disfunkcija m. bešike; rehabilitacija Neurogenic bladder dysfunction, resulted from demage to the neural structures in spinal lesion present a major problem for the patient, his environment and health care workers. Proper diagnosis of neurogenic bladder dysfunction allows you to implement appropriate treatment plan that will allow adequate emptying and prevention of complications that may endanger the patient's life .The evolution of spinal cord injuries can distinguish three phases: 1) spinal shock phase, 2) the recovery phase, 3) final phase. After spinal trauma bladder is affected mostly in two ways: 1) Spastic (reflex) bladder caused in lesion above voiding center (S2-S4 segments), 2) Flaccid (atonic) neuropathic bladder emerges in lesion at the voiding center (S2-S4) or below it, as well as lesions of the peripheral innervation of bladder, 3) Autonomic disreflection syndrome develops in patient with cervical or high thoracic spinal cord lesions, above the Th 1 segment, 4) Uninhibited neurogenic bladder develops in incomplete nerve pathway lesions in cerebral cortex, pyramidal pathway or in spinal cord -cerebral voiding control debilitate.The diagnosis of neurogenic bladder dysfunction is established ...
Application of organic heterocyclic compounds as anti-tumor therapeutics are limited due to therapeutic drawbacks including resistance of tumor cells, nonselectivity of the administered drug towards healthy cells and abundance of unwanted side effects. The aim of our research was to investigate and compare both the antitumor effect and the mechanism of action of newly synthesized, so far untested chalcone analogue on HeLa, HCT-116 cells and healthy human fibroblast lung cell line (MRC-5). The antitumor efficiency of investigated chalcone analogue was compared to the antitumor effects of dehydrozingerone and cysplatin that were used as referent substances. Cytotoxic and apoptotic effect were evaluated using both MTT test and flow cytometry by Annexin V-FITC/7-AAD staining. The results of our investigation indicated that newly synthesized chalcone analogue H5 expressed more powerful antitumor effect compared to the effects of both dehydrozingerone and cisplatin. Cell death was mediated via apoptotic pathway.
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