Background: Hypertension, itself being a major chronic condition, is one of the most significant risk factors for premature cardiovascular diseases and mortality. Hypertension is responsible for 13% of global deaths and threequarters of the world's hypertensive population reside in low-and middle-income countries. Bangladesh is one of those countries that experiencing an epidemiological transition from communicable to non-communicable diseases, a nutritional transition from a traditional diet to process and fast food, and an increase in a sedentary lifestyle, resulting in increased hypertension prevalence. We carried out a systematic review and meta-analysis to identify existing research on hypertension prevalence in Bangladesh, summarize findings and assess its temporal change. Methods: We searched MEDLINE, EMBASE and PubMed and relevant references to identify studies on the prevalence of hypertension in Bangladesh. We used Random-effects meta-analysis to pool the prevalence estimates and performed subgroup analyses. We assessed heterogeneity, a trend in prevalence of hypertension and publication bias in selected studies. Results: Our search initially identified 735 articles and after removing duplicates, reviewing titles and abstracts, and screening full texts, 53 studies were finally selected. The studies comprised 305,432 subjects and reported overall, gender-specific, geographical location specific and criteria specific prevalence of hypertension. We identified the range of hypertension prevalence is from 1.10% to 75.0% and the overall weighted pooled prevalence of hypertension is 20.0%. An extremely high heterogeneity (I 2 = 99.53%; Cochran Q-statistic p < 0.001) was observed in the prevalence of hypertension. Consequently, we performed subgroup analysis based on gender, age group and geographical location of the study participants, the cutoff level used to define hypertension, and the types of hypertension reported and presented our findings accordingly. An overall increasing trend of hypertension prevalence is also observed. Conclusions: The prevalence of hypertension is high and rising in Bangladesh. Strategies targeting prevention are required to mitigate a further increase in the prevalence and reduce the morbidity and mortality associated with it.
Abstract. The role of regucalcin, a regulatory protein in intracellular signaling system, in the regulation of Ca 2+ -ATPase activity in rat heart mitochondria was investigated. Mitochondrial Ca 2+ -ATPase activity was significantly increased by increasing concentrations of CaCl 2 (2.5-50 μM). An increase in the enzyme activity was saturated at 50 μM CaCl 2 . The addition of regucalcin (10 -11 -10 -8 M) in the enzyme reaction mixture caused a significant increase in Ca 2+ -ATPase activity in heart mitochondria in the presence of 50 μM CaCl 2 . Regucalcin did not have a significant effect on mitochondrial Mg 2+ -ATPase activity. Regucalcin (10 -9 M) did not have a significant effect on Ca 2+ -ATPase activity in the presence of digitonin (10 -3 or 10 -2 %), which is a solubilization effect on membranous lipids. The effect of regucalcin in increasing mitochondrial Ca 2+ -ATPase activity was not observed in the presence of ruthenium red (10 -7 M) or lanthanum chloride (10 -7 M), which is an inhibitor of Ca 2+ uniporter. The effect of regucalcin (10 -9 M) in increasing mitochondrial Ca 2+ -ATPase activity was not significantly enhanced in the presence of calmodulin (5 μg/ml) or dibutyryl cyclic AMP (10 -4 M), which is an intracellular signaling factor that can cause a significant increase in the enzyme activity. Mitochondrial regucalcin localization was significantly increased in the heart of regucalcin transgenic rats as compared with that of normal rats using Western blot analysis. Ca 2+ -ATPase activity was significantly increased in the heart mitochondria of regucalcin transgenic rats. This study demonstrates that regucalcin has an activating effect on Ca 2+ -ATPase in rat heart mitochondria, suggesting its role in the regulation of heart mitochondrial function.
Wildlife markets are hotspots for illegal wildlife trade, with traders operating as a result of weak monitoring and law enforcement. Knowledge of species traded, sources, and routes used for transport is needed to identify illegal wildlife trade markets and intervene to stem trade. We conducted surveys in 13 wildlife markets across Bangladesh every month during January-December 2019 to assess the abundance and diversity of wildlife taxa traded and the factors driving this trade. Passeriformes, Columbiformes, Psittaciformes, Artiodactyla, Carnivora and Testudines were the most traded orders. Wildlife markets were also centres of trade for high-value species, including the tiger Panthera tigris, crocodile Crocodylus porosus and tortoises. In hill markets and peri-urban markets the most commonly sold species originated from nearby forests, whereas urban markets included both native species and exotic species sourced internationally. Market type, road links to the market, the presence of law enforcement agencies, proximity to a port and form of sale (live animals or byproducts) all significantly influenced what is being traded. Trade of mammals, reptiles, high-value wildlife species and threatened species was less common in markets proximal to law enforcement agencies. Markets close to seaports or airports were more likely to sell mammals, threatened species and high-value wildlife. Based on our results, we recommend a set of interventions to help reduce market-based wildlife trade in Bangladesh.
Abstract. The expression of regucalcin, a regulatory protein in the intracellular signaling system, in the hearts of rats was investigated. Regucalcin expression was examined using reverse transcription-polymerase chain reaction and Western blot analysis. Regucalcin mRNA and its protein levels in the hearts of male and female rats were significantly decreased with increasing age (50 weeks old) as compared with that of 5-week-old rats. The effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH), a compound that produces free radical, on regucalcin mRNA expression in the hearts of female rats (5 weeks old) was examined. Heart regucalcin mRNA levels were significantly decreased at 60 or 180 min after a single intraperitoneal administration of DPPH (0.5 mg /100 g body weight), suggesting that free radical stress has a suppressive effect on the gene expression. Normal (wild) female rats died at approximately 300 min after a single intraperitoneal administration of DPPH (0.5 mg/100 g), while regucalcin transgenic (TG) female rats died at approximately 150 min after the administration. Heart regucalcin protein in DPPHadministered rats was greater in regucalcin TG rats than in normal (wild) rats. This study demonstrates that the death of regucalcin TG rats is accelerated after the administration of free radical compound, indicating that overexpression of regucalcin does not have effects as the suppressor for free radical stress and the scavenger for free radical in rats.
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