ABSTRACT. We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the First Affiliated Hospital of Guangxi Medical University. The genotyping of the gene polymorphisms was conducted using the polymerase chain reaction coupled with restriction fragment length polymorphism. By logistic regression analysis, we found that the AA genotype of ERCC1 rs3212986 was associated with lower rates of complete remission and partial remission following chemotherapy in gastric cancer patients, and the OR (95%CI) was 0.19 (0.06-0.60). We found that the AA genotype of rs3212986 was correlated with higher risk of death from gastric cancer according to the Cox proportional hazards model, and the adjusted HR (95%CI) was 1.60 (0.81-3.16). However, we found no association between ERCC1 rs11615, ERCC2 rs13181, and ERCC2 rs1799793 and overall survival of gastric cancer. In conclusion, the results of the present retrospective study indicate that the ERCC1 rs3212986 gene polymorphism has a significant effect on the pharmacokinetics and treatment outcome of gastric cancer.

Zn0.86Co0.14O powder and thin films were prepared by standard solid-state reaction processes and radio-frequency (RF) magnetron sputtering. Magnetic measurements indicate that the powder is paramagnetic for temperatures above 3 K, while the thin films annealed in vacuum are ferromagnetic at room temperature. The saturated magnetization was found to be about 0.6 microB/Co, while the coercive force was found to be 200 Oe at room temperature. The very similar results were also obtained in Zn0.96Mn0.04O powder and thin films. Such different results for the powder and thin films indicate that growth conditions and defects play an important role in producing ferromagnetism.