Parkinson’s Disease (PD) is a disease that involves neurodegeneration and is characterised by the motor symptoms which include muscle rigidity, tremor, and bradykinesia. Other non-motor symptoms include pain, depression, anxiety, and psychosis. This disease affects up to ten million people worldwide. The pathophysiology behind PD is due to the neurodegeneration of the nigrostriatal pathway. There are many conventional drugs used in the treatment of PD. However, there are limitations associated with conventional drugs. For instance, levodopa is associated with the on-off phenomenon, and it may induce wearing off as time progresses. Therefore, this review aimed to analyze the newly approved drugs by the United States-Food and Drug Administration (US-FDA) from 2016–2019 as the adjuvant therapy for the treatment of PD symptoms in terms of efficacy and safety. The new drugs include safinamide, istradefylline and pimavanserin. From this review, safinamide is considered to be more efficacious and safer as the adjunct therapy to levodopa as compared to istradefylline in controlling the motor symptoms. In Study 016, both safinamide 50 mg (p = 0.0138) and 100 mg (p = 0.0006) have improved the Unified Parkinson’s Disease Rating Scale (UPDRS) part III score as compared to placebo. Improvement in Clinical Global Impression—Change (CGI-C), Clinical Global Impression—Severity of Illness (CGI-S) and off time were also seen in both groups of patients following the morning levodopa dose. Pimavanserin also showed favorable effects in ameliorating the symptoms of Parkinson’s Disease Psychosis (PDP). A combination of conventional therapy and non-pharmacological treatment is warranted to enhance the well-being of PD patients.

In this paper, the authors aim to analyse organisational intention and focus on hybrid project management (HPM) methodology adoption in FinTech system software development. It is important to ascertain the internal and external factors that affect organisational decision-makers’ intentions towards HPM adoption. This study aims to apply a theoretical approach integrating Technology-Organisation-Environment (TOE), which examines the factors that impact FinTech organisations’ decisions to adopt HPM into their software development projects, together with the Theory of Planned Behaviour (TPB) which examines the behavioural intention. It addresses those factors that form organisational decision-makers’ readiness for HPM implementation and enable their intention to use it. When combining the independent, dependent, and moderating variables, the results show that the effect of relative advantage, top management support, and industry pressure have a positive influence on individual’s attitude towards HPM adoption in FinTech Malaysia and sustainability in Quality 4.0. The authors also considered the influence of attitudes and perceived behavioural control variables having a positive influence on sustainable intention of HPM adoption in the FinTech industry. Partial Least Squares Structural Equation Modelling (PLS-SEM) was used to verify the proposed hypotheses, with the exception of the direct influence of top management support or attitude on intention to adopt.