In this group of overweight children, hemoglobin A1c decreased significantly after participating in a multi-disciplinary weight loss program. These findings further point to the beneficial effect of lifestyle changes on the metabolic status of obese children.
Aim: The objective of this study was to compare hemoglobin A1c values in non‐diabetic obese children and adolescents before enrollment and after completion of a 12‐wk weight management program. Methods: Seventeen children and adolescents, age 10.8±2.5 y (mean±1 SD), joined a multidisciplinary weight management program. Hemoglobin A1c and body mass index were measured at the start and at the completion of the program in each participant. Results: Body mass index at the start of the program was 34.3±6.4 kg/m2. Body mass index at the end of the program was 33±6.6 kg/m2 (p<0.05). Hemoglobin A1c at the beginning of the program was 5.3±0.3%. Hemoglobin A1c at the completion of the program was 5±0.2% (p<0.05). Conclusion: In this group of overweight children, hemoglobin A1c decreased significantly after participating in a multi‐disciplinary weight loss program. These findings further point to the beneficial effect of lifestyle changes on the metabolic status of obese children.
Purpose of reviewBardet Biedl syndrome (BBS) is a rare disease characterized by obesity and hyperphagia. Despite the very high prevalence of paediatric and adult obesity in this population, the prevalence of diabetes mellitus is not well described.Recent findingsStudies in small and moderately large cohorts suggest a high prevalence of traditional risk factors for diabetes mellitus in people with BBS. People with BBS appear to have a high prevalence of insulin resistance and metabolic syndrome. Small cohort studies have identified high rates of sleep disordered breathing, including sleep apnoea syndrome. Recent research has characterized traditional behavioural risk factors such as sleep hygiene and physical inactivity in people with BBS. High rates of insufficient sleep and prolonged sedentary time suggest behavioural targets of interventions to treat or prevent diabetes mellitus. Hyperphagia, likely caused by defects in the hypothalamic melanocortin-4 receptor (MC4R) neuronal pathway, pose additional challenges to behavioural interventions to prevent diabetes mellitus.SummaryUnderstanding the prevalence of diabetes mellitus and other metabolic disorders in people with BBS and the impact of traditional risk factors on glucose regulation are important to developing effective treatments in this population.
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