The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.
Two Cu II complexes with a new quinoline sulfonamide derivative and phenanthroline (phen), [Cu(QSQ)-(phen)]ClO 4 ·0.5H 2 O (1) and [Cu(QSQ)(phen)(H 2 O)]ClO 4 (2) [HQSQ = N-(quinolin-8-yl)quinolin-8-sulfonamide], have been synthesized and physicochemically characterized. Single-crystal X-ray diffraction studies have revealed a highly distorted trigonal-bipyramidal structure for 1 (τ = 0.68) and an almost perfect trigonal-bipyramidal geometry for 2 (τ = 0.92). DNA binding studies, which were performed by thermal denaturation, viscometry, fluorescence spectroscopy, and cyclic voltammetry, [a] 982 Scheme 1. Synthesis of N-(quinolin-8-yl)quinolin-8-sulfonamide (HQSQ) and complexes 1 and 2. Eur. J. Inorg. Chem. 2016, 982-994 www.eurjic.org Nuclease Activity: The reactions were performed with pUC18 and 1 in 0.1 M cacodylate buffer at pH 6.0. The complex solution was initially prepared in DMF and then diluted with cacodylate buffer. Eur. J. Inorg. Chem. 2016, 982-994 www.eurjic.org
The development of systems for targeted delivery of Sorafenib in unresectable hepatocellular carcinoma to reduce the systemic toxicity is a challenge. In our article, we successfully prepared core‐shell microcapsules based on bovine serum albumin gel with polyelectrolyte complex multilayer shell of polysaccharides with opposite charges, hyaluronic acid, and chitosan, encapsulating Sorafenib, as targeting delivery system for improved hepatocellular carcinoma therapy. A bovine serum albumin gel core was formed by a method based on a sacrificial CaCO3 template, followed by the multilayer shell build‐up of Ca2+ cross‐linked hyaluronic acid hydrogel, and subsequently alternating multilayers of the polyelectrolyte complex formed between hyaluronic acid and chitosan. The following techniques: Fourier‐transform infrared and UV–Vis spectroscopy, X‐ray diffraction, differential scanning calorimetry, confocal laser scanning microscopy, atomic force microscopy, and scanning electron microscopy were used for the physicochemical characterization. These tests revealed the spherical shape of core‐shell type, the micro‐size, as well as the composition of microcapsules after their synthesis and proved the successful encapsulation and release of the drug. The promising results regarding encapsulation efficiency, Sorafenib release profile and cytotoxicity on HepG2 and mesenchymal stem cells, recommend Sorafenib loaded microcapsules as suitable targeted drug carriers for further in vivo studies for hepatocellular carcinoma therapy.
The serious health issues raised by microbial resistance to first-line and last-resort antibiotics have triggered the search for efficient strategies to prevent and treat infections. Metal coordination of structures with antibacterial properties represents a promising approach in improving and refining the biological activity of both antibiotics and metal ions as it provides the opportunity to design compounds with unique and tunable features. Sulfonamides in particular are an interesting choice since they combine the structural characteristics required for both antibacterial activity and metal coordination. The present paper reviews the reports on the antimicrobial properties of complexes of metal ions coordinating sulfonamides widely used in the therapy of infections over the past decades.
RezumatIdentificarea unor soluții fezabile care sӑ rezolve problema rezistenței la antibiotice rӑmâne o provocare continuӑ pentru cercetӑtori, determinând de-a lungul timpului dezvoltarea unor strategii eficiente de prevenție și tratare a infecțiilor bacteriene. Obținerea unor compuși prin coordinarea ionilor metalici cu liganzi ce prezintӑ activitate antibacterianӑ consacratӑ reprezintӑ o abordare promițӑtoare privind proiectarea de noi compuși mai eficienți din punct de vedere al acțiunii antimicrobiene. În acest sens, sulfonamidele reprezintӑ o alegere interesantӑ deoarece combinӑ caracteristicile structurale necesare atât pentru activitatea antibacterianӑ cât și pentru funcționarea lor ca liganzi în chimia coordinativӑ. Lucrarea de fațӑ aduce informații actuale privind proprietӑțile antimicrobiene ale complecșilor metalici ai unor sulfonamide utilizate pe scarӑ largӑ în ultimele decenii în tratarea infecțiilor bacteriene.
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