Results: 76 patients were included. Patient characteristics and toxicities are summarized in the table. 55.3% patients presented toxicity: 30.9%, 45.2% and 23.8% grade I, II and III respectively (attending CTCAE v5.0).
and public hospitals, inside hospital pharmacies and at the patient's home. The Recommendation is to protect patients needing anticancer drug treatments. Highlight: the hospital should provide working instruments and develop a procedure including all instructions for proper anticancer drug management. They also have to: draw up a Patient Safety Training Plan, promote communication and integration among health professionals, provide accurate and complete information to patients and their families, consider the psychological and emotional state of patients and give detailed indications for the delivery of drugs at discharge. Conclusions The Recommendation is a reference for health professionals involved in handling anticancer drugs, providing information about the patient's objectives and expected benefits from treatment. The document provides guidance aimed at preventing errors that can occur during anticancer drug treatment and includes recommendations encouraging the promotion of clinical governance. A verification of this Recommendation is expected soon. Many experts gave their suggestions to facilitate its implementation. No conflict of interest. Reconciliation and dRug infoRmation to geRiatRic Polymedicated Patients at dischaRge using infoRmation technology
Background
Good adherence to hepatitis C treatment seems necessary to obtain a successful treatment, increasing sustained virological response (SVR) rates.
Purpose To assess the adherence to chronic hepatitis C treatment.
Materials and Methods The study was descriptive, retrospective and observational. Patients with chronic hepatitis C, who were being treated with peginterferon and ribavirin or monotherapy with peginterferon in 2011, were selected. Data collected were: age, drug dispensed, duration of treatment, pretreatment, co-infected status (HIV, HBV), haemophilia status, genotype and viral load at the beginning and the end of treatment. Adherence was calculated taking into account the number of medicines dispensed and the dates.
Results
Of the 113 patients included (102 adults, 11 children) 110 patients were treated with ribavirin and peginterferon. The other three patients were treated with only peginterferon. There were 32 patients with HIV co-infection and three haemophiliacs. The average adherence of 112 of patients was 103%; one patient had less than 85% adherence. The genotype 1 patients (n = 54) had a mean duration treatment time of 35.5 weeks and a mean adherence of 103%. The genotype non-1 patients (n = 59) had a mean duration of treatment of 28.3 weeks and 104% adherence. The SVR of patients with genotype 1 and non-1 were 50% and 60% respectively.
Conclusions
There was a high rate of adherence to treatment because it has a definite time course. Adherence was greater than 100% owing to some patients coming to pick up the medicines before the set date. The method used in this study could be improved with validated adherence questionnaires. Good adherence is necessary to achieve SVR and it is especially important with the new protease inhibitors drugs (boceprevir and telaprevir), due to the complexity of triple therapy, adverse reactions and the high cost. Therefore, hospital pharmacists should collaborate on it with pharmaceutical care clinics specialising in hepatitis C.
No conflict of interest.
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