We
report controlled migrations of an intelligent and biocompatible
“iMushbot” composed of Agaricus bisporus, mushroom microcapsules coated with magnetite nanoparticles. The
otherwise randomly moving microbot could meticulously direct itself
toward and away from the acid- and alkali-rich regions with the help
of acid, acidic catalase, and alkali stimuli, emulating the chemotaxis
of microorganisms. Although the catalytic decomposition of peroxide-fuel
in alkali engendered the directed alkali taxis toward higher pH region,
decomposition of peroxide fuel by the acidic catalase activity led
to directed acid taxis toward the lower pH region. The presence of
magnetite nanoparticles not only helped in improving the “activity”
of the motor through the heterogeneous catalytic decomposition of
the peroxide fuel but also provided a remote magnetic control on the
chemotaxis. The mesoporous iMushbots having negative ζ-potential
could easily be loaded with the cationic anticancer drugs, which were
magnetically guided toward the cancerous cells to cause apoptosis.
The iMushbots exhibited higher degree of drug retaining capacity inside
alkaline pH and showed facile drug release preferentially in the lower
pH environments. The experiments show the potential of the iMushbots
in retaining and transporting drugs in alkaline medium such as human
blood and releasing them in acidic medium such as the cancerous tissues
for cell apoptosis.
The present study reports the synthesis of pure and Cu-doped ZnO nanorods for antibacterial and photocatalytic applications. The samples were synthesized by simple, low cost mechanical-assisted thermal decomposition process. The synthesized materials were characterized by scanning electron microscopy, UV-Visible spectroscopy, and photoluminescence studies. The antibacterial activity of characterized samples was determined against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes and Gram-negative bacteria such as Escherichia coli using shake flask method with respect to time. The significant antibacterial activity was perceived from scanning electron micrographs that clearly revealed bacterial cell lysis resulting in the release of cytoplasmic content followed by cell death. The degradation of methylene blue was used as a model organic dye for photocatalytic activity. The present study demonstrates the superior photocatalytic and antibacterial activity of Cu-doped ZnO nanorods with respect to pure ZnO nanorods.
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