Marchantia polymorpha L. is used as a folk medicine in India, China and some European countries for the treatment of inflammation, cure cuts, wounds, diuretics, etc. Natural compounds and biological activities of this liverwort have been studied in the world for few years. At present time, the studies on bryophytes (non-vascular plants) are quite limited, especially in Vietnam. Therefore, this research focused on investigating some biological activities and analyzing of major secondary metabolites of M. polymorpha L. collected at Da Lat, Lam Dong. Among four extracted fractions (nhexane, chloroform, ethyl acetate and ethanol), the chloroform extract exhibited the best antioxidant, antibacterial, anti-proliferation of MCF-7 cell line activities. The ethyl acetate extract exhibited better activity of tyrosinase and α-glucosidase inhibition than others. Main secondary compounds in this species were phenolics, steroids and glycosidederivatives. These results were scientific evidences that might help us to understand rigorously about the ultilization of Marchantia liverwort in the traditional treatment and new potential applications in the contemporary medicine.
At the present time, non-vascular plants (bryophytes) are less studied, especially in Vietnam. Therefore, this research focuses on studying biological activities of some bryophytes species collected in Bidoup–Nui Ba National Park, such as antioxidative, antibacterial activity, acetylcholinesterase inhibitory activity and quantitative analysis of the major secondary metabolites. Moreover, one of the most potential species was micropropagated in vitro in order to get the initiative pharmaceutical materials. Among the six bryophyte species collected in Bidoup–Nui Ba National Park, three of them are mosses (Pyrrhobryum spiniforme, Bryum argenteum and Campylopus umbellatus) and three of them are liverworts (Lepidozia fauriana, Plagiochila trabeculata and Schistochila blumei). Our results showed that L. fauriana had the highest antioxidative activity and acetylcholinesterase inhibitory activity (IC50 = 6.617 ± 0.080 mg/mL), S. blumei had the potent antibacterial activity. In vitro propagation results showed that silver moss could be micropropagated using spores in MS medium supplemented with 1 mg/L 2,4-D and 2 mg/L kinetin.
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