LFCT can be reliably measured and is prolonged in patients with OSA and underlying HF. LFCT based on PSG may be a useful marker for detection of coexisting HF in patients with OSA.
Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents. Developing a better understanding of serotonin syndrome is essential for the prevention and management of this potentially life-threatening condition. This report describes a patient with schizophrenia, depression, and severe, acute osteomyelitis. The patient was taking multiple serotonergic agents and required the use of linezolid without the possibility of a sufficient washout period. The severity of the patient's condition in conjunction with increased risk for serotonin syndrome warranted prophylactic treatment with cyproheptadine. The complex pathophysiology of prophylactic treatment of serotonin syndrome with cyproheptadine is worthy of discussion.
Background: Aerobic Exercise is a host of health benefits to reduce vigor risk and maintain body weight. The purpose of the present investigation is to determine the influence of aerobic exercises on body weight and Metabolic Equivalent of Task (MET)activity among cardiac rehabilitation phase II patients.The objective of the study is to investigate the impact of obesity on the efficacy of aerobic capacity.Methods: Fifteen obese (ten males, five females) and fifteen non-obese (eleven males, four females) participants of phase II cardiac rehabilitation were selected from a tertiary care hospital by their Body Mass Index (BMI). They were divided into two groups by simple random technique. Aerobic exercises were given for 12 weeks for post-CABG cardiac rehabilitation phase II obese and non-obese(healthy and overweight) patients. BMI and the Metabolic equivalent of task activity of cardiac rehabilitation phase II patients are measured by enrolling a patient in 12 weeks of aerobic exercises program.
Results:The aerobic exercise shows a positive result in both obese and non-obese patients. Aerobic exercises improved metabolic equivalent of task in both obese(4.6667+_0.65134 ;< 0.05) and non-obese patients (4.6923+_.48038 ;< 0.05) significantly. But aerobic exercises were more effective in enhancing the efficacy of aerobic capacity in obese patients.
Conclusion:It is evident that aerobic exercises are more effective for obese patients to maintain or reduces weight. Higher MET activity was observed in obese patients.
Complex sleep apnea (CompSA) is defined as the development of central events during a continuous positive airway pressure (CPAP) titration in a patient with obstructive sleep apnea (OSA). We hypothesized that patients with OSA on chronic opioids would fail a CPAP titration more frequently than patients with OSA not on opioid therapy and that the increased failure rate would be due to a greater prevalence of CompSA. In a retrospective chart review, we identified 58 patients with OSA on opioids and compared them to 150 patients with OSA not on opioids. CPAP titration failure was defined as an apnea‐hypopnea index greater than 5/h at all CPAP pressures tested. CompSA was defined as the development of a central apnea index greater than 5/h during the CPAP titration study. Nineteen of the 58 patients (32.8%) with chronic opioid use and 18 of the 150 (12.0%) in the control group had CPAP titration failure (P‐value 0.001). Six of the 49 patients (12.2%) with pure OSA in the opioid group and 5 of the 146 (3.4%) with pure OSA in the control group developed CompSA (odds ratio: 3.93; 95% confidence interval: 1.14–13.52; P‐value: 0.03). Logistic regression showed that opiate use still predicted the presence of CompSA after coronary artery disease, hyperlipidemia, antidepressant usage and benzodiazepine use were accounted for. Patients on chronic opioid therapy had a higher percentage of treatment failure, and this was secondary to a higher prevalence of CompSA and persistence of central events seen on the diagnostic sleep study.
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