Herein,
we describe the first oxysilylation of unsaturated carboxylic
acids mediated by di-tert-butyl peroxide (DTBP),
which enables the rapid and efficient preparation of silyl lactone
compounds. This process tolerates functional groups, such as methyl,
methoxy, halogen (fluoride and chloride), and cyano moieties. Furthermore,
the strategy allows the application of a wide range of primary, secondary,
and tertiary hydrosilanes for functionalization.
An S N 2-type trifluoromethylation of benzyl halides under transition-metal-free conditions has been developed using trifluoromethyltrimethylsilane (CF 3 SiMe 3 , Ruppert À Prakash reagent) and CsF in 1,2-dimethoxyethane (DME). Under the developed reaction conditions, the in situ generated trifluoromethyl anion (CF 3 À ) overcame the instability and displayed enhanced nucleophilicity in the presence of DME. This method provides an efficient approach for the generation of various (2,2,2-trifluoroethyl)arenes such as those bearing alkyl, alkoxy, halo (F, Cl, and Br) and trifluoromethyl groups on the benzene rings.
Alizarin red S (ARS) was confined in layer-by-layer (LbL) films composed of phenylboronic acid-modified poly(ethyleneimine) (PBA-PEI) and carboxymethylcellulose (CMC) to study the voltammetric response to diol and polyol compounds. The LbL film-coated gold (Au) electrode and quartz slide were immersed in an ARS solution to uptake ARS into the film. UV-visible absorption spectra of ARS-confined LbL film suggested that ARS formed boronate ester (ARS-PBS) in the film. The cyclic voltammetry of the ARS-confined LbL film-coated electrodes exhibited oxidation peaks at −0.50 and −0.62 V, which were ascribed to the oxidation reactions of ARS-PBS and free ARS, respectively, in the LbL film. The peak current at −0.62 V increased upon the addition of diol or polyol compounds such as L-dopa, glucose, and sorbitol into the solution, depending on the concentration, whereas the peak current at −0.50 V decreased. The results suggest a possible use of ARS-confined PBA-PEI/CMC LbL film-coated Au electrodes for the construction of voltammetric sensors for diol and polyol compounds.
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