With 200 SEPs of normal human subjects, the sex differences in the waveform of the Group Mean SEP were established eliminating those attributable to the peripheral factors, the statures and the nutritional conditions represented by Rohrer's index. The differences in baseline amplitude of the Group Mean SEP between sexes, in the sections between 25–110 msec and behind 400 msec in latency, were verified removing those between the tallers and the shorters and those between with high and with low values of Rohrer's index, not attributable to these peripheral factors and might be the central origin. The differences in the Scaled Group Mean SEP were also verified similarly, being more a significant indication of the sex difference itself than those in the Group Mean SEP.
Summary
The effect of Thiopental on the human somatosensory evoked response (E.R.) recorded on the scalp was studied in chronic schizophrenic patients. The E.R. was recorded successively before, during and after the intravenous injection of different dosages of Thiopental until after awakening. The changes in the latencies of the main positive peak and the main negative peak and the changes in the amplitude were analyzed quantitatively, comparing with the mean latency and the mean amplitude before injection.
I observed a systematic change in latency, which increased and recovery was delayed proportional to the dosage. Among the peaks constituting the major positive peak, the latency of the later peak increased more, regardless of its polarity. The latency of the main positive peak increased without drug induced sleep. On an average, the increase without sleep is the same as the level to which the latency recovered when awakening occurred (125%).
The changes in amplitude were inconsistent. There was a tendency to decrease at the beginning, but the individual changes differed markedly among subjects and dosages. Although it can not be applied in all subjects, analysis revealed two phases during the drug induced sleep. The later phase accompanied by characteristic E.R. pattern with augmented the first positive peak was attributed to the postnarcotic sleep. With larger dosages, synchronization of the EEG in beta frequency to the peripheral stimulation occurred first prior to the appearance of E.R.
The 3 year outcome of 48 residents in a special nursing home was investigated, using Hasegawa's dementia rating scale (HDS) and activities of daily living (ADL). For all the residents, HDS score correlates well with age (P < 0.01) and ADP score (P < 0.001). Nineteen residents (40.4%) died during the period surveyed. Two-thirds of the residents with low ADL score died during the period, whereas 70% of the residents with high ADL score are alive. Of these scales, ADL correlated well with the fatal prognosis, suggesting that ADL is a valuable prognostic tool. As for the causes of death, pulmonary disease was prominent (n = 12, 63.2%). Consequently, the prevention of pulmonary disease is needed to achieve a good outcome in the management of nursing home residents.
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