To clarify the effects of anti-allergic drugs on substance P (SP) and vasoactive intestinal peptide (VIP) levels in nasal secretions, we employed competitive enzyme-linked immunoassays to measure concentrations of those neuropeptides in nasal secretions from 40 patients with house dust nasal allergy before and after administration of azelastine and oxatomide. One mg of azelastine and 30 mg of oxatomide were administrated twice a day for 4 weeks. Mean values of SP concentrations and ratios of SP to total protein of the nasal allergy group were significantly higher than those of the control group (p < 0.002). The VIP/total protein ratio of the allergy group was also significantly higher than that of the control group, although the VIP concentration alone was not. Mean levels of SP and VIP from patients with severe symptoms were significantly higher than those of the control group (p < 0.05), although those values were not significantly different between patients with moderate symptoms and control subjects. Azelastine and oxatomide effectively reduced SP levels in nasal secretions (p < 0.005), but they did not significantly decrease VIP levels. The reduction of SP levels was significant in patients with excellent responses to those drugs (p < 0.005), but not in patients with poor responses. These findings suggest that SP and VIP levels in nasal secretions may reflect the clinical state of nasal allergy and be one of the better parameters available for evaluating the clinical efficacy of anti-allergic drugs against nasal allergy.
We studied 86 cases of orbital blowout fracture treated in our in-patient department between October 1981 and June 1999. Orbital floor fractures occurred in 51 cases , medial orbital wall fractures occurred in 12 cases, and both types occurred in 23 cases . Surgery was performed in 79 of these cases under general anesthesia.
4) Pelikan Z, Pelikan-Filipek M: Role of nasal allergy in chronic maxillary sinusitis-Diagnostic value of nasal challenge with allergen. J Allergy Clin Immunol 86: 484-491, 1991. 10) Kelly RW, Graham BJM, O'sullivan MJ: Measurement of PGE2 as the methyl oxime by radioimmunoassay using a novel lodinated label , Prostaglandins,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.