A new Super-Kamiokande (SK) search for Supernova Relic Neutrinos (SRNs) was conducted using 2853 live days of data. Sensitivity is now greatly improved compared to the 2003 SK result, which placed a flux limit near many theoretical predictions. This more detailed analysis includes a variety of improvements such as increased efficiency, a lower energy threshold, and an expanded data set. New combined upper limits on SRN flux are between 2.8 and 3.0νe cm −2 s −1 > 16 MeV total positron energy (17.3 MeV Eν).

The results of the third phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first and second phase results. With improved detector calibrations, a full detector simulation, and improved analysis methods, the systematic uncertainty on the total neutrino flux is estimated to be ±2.1%, which is about two thirds of the systematic uncertainty for the first phase of Super-Kamiokande. The observed 8 B solar flux in the 5.0 to 20 MeV total electron energy region is 2.32± 0.04 (stat.) ± 0.05 (sys.) ×10 6 cm −2 sec −1 under the assumption of pure electron-flavor content, in agreement with previous measurements. A combined oscillation analysis 2 is carried out using SK-I, II, and III data, and the results are also combined with the results of other solar neutrino experiments. The best-fit oscillation parameters are obtained to be sin 2 θ12 = 0.30 by adding KamLAND result. In a three-flavor analysis combining all solar neutrino experiments, the upper limit of sin 2 θ13 is 0.060 at 95% C.L.. After combination with KamLAND results, the upper limit of sin 2 θ13 is found to be 0.059 at 95% C.L..

We present the result of an indirect search for high energy neutrinos from Weakly Interacting Massive Particle (WIMP) annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Data sets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C.L. upper limits of upmu flux induced by WIMPs of 100 GeV c -2 were 6.4 × 10 −15 cm −2 s −1 and 4.0 × 10 −15 cm −2 s −1 for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5 × 10 −39 cm −2 and 2.7 × 10 −40 cm −2 for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively.

Plasma free amino acid (PFAA) profile is highlighted in its association with visceral obesity and hyperinsulinemia, and future diabetes. Indeed PFAA profiling potentially can evaluate individuals’ future risks of developing lifestyle-related diseases, in addition to diabetes. However, few studies have been performed especially in Asian populations, about the optimal combination of PFAAs for evaluating health risks. We quantified PFAA levels in 3,701 Japanese subjects, and determined visceral fat area (VFA) and two-hour post-challenge insulin (Ins120 min) values in 865 and 1,160 subjects, respectively. Then, models between PFAA levels and the VFA or Ins120 min values were constructed by multiple linear regression analysis with variable selection. Finally, a cohort study of 2,984 subjects to examine capabilities of the obtained models for predicting four-year risk of developing new-onset lifestyle-related diseases was conducted. The correlation coefficients of the obtained PFAA models against VFA or Ins120 min were higher than single PFAA level. Our models work well for future risk prediction. Even after adjusting for commonly accepted multiple risk factors, these models can predict future development of diabetes, metabolic syndrome, and dyslipidemia. PFAA profiles confer independent and differing contributions to increasing the lifestyle-related disease risks in addition to the currently known factors in a general Japanese population.

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The results of the second phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first phase. −0.15 (sys.)) × 10 6 cm −2 sec −1 and the day-night difference is found to be (−6.3 ± 4.2(stat.) ± 3.7(sys.))%. There is no evidence of systematic tendencies between the first and second phases.

Elucidation of maternal immune correlates of protection against congenital cytomegalovirus (CMV) is necessary to inform future vaccine design. Here, we present a novel rhesus macaque model of placental rhesus CMV (rhCMV) transmission and use it to dissect determinants of protection against congenital transmission following primary maternal rhCMV infection. In this model, asymptomatic intrauterine infection was observed following i.v. rhCMV inoculation during the early second trimester in two of three rhCMV-seronegative pregnant females. In contrast, fetal loss or infant CMV-associated sequelae occurred in four rhCMV-seronegative pregnant macaques that were CD4 + T-cell depleted at the time of inoculation. Animals that received the CD4 +

A search for Supernova Relic Neutrinosν e 's is first conducted via inverse-beta-decay by tagging neutron capture on hydrogen at Super-Kamiokande-IV. The neutron tagging efficiency is determined to be (17.74 ± 0.04 stat. ± 1.05 sys. )%, while the corresponding accidental background probability is (1.06 ± 0.01 stat. ± 0.18 sys. )%. Using 960 days of data, we obtain 13 inverse-beta-decay candidates in the range of Eν e between 13.3 MeV and 31.3 MeV. All of the observed candidates are attributed to background. Upper limits at 90% C.L. are calculated in the absence of a signal.