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The first direct X-ray crystal structure determination of a cytotoxic cyclic peptide from ascidian, ascidiacyclamide, has shown a molecular conformation responsible for its biological activity.

SzGmmaryThe Diels-Alder adduct between ergosterol synthesised in labelled form and shown to be an efficient acetate and 4-phenyl-lJ2,4-triazolin-3,5-dione can be precursor of ergosterol in yeast. efficiently re-converted into ergosterol by lithium aluminium hydride reduction ; using this reaction as a DURING work on ergosterol biosynthesisf we required radiokey step, ergosta-5,7,22,24(2S)-tetraen-3/!?-01 has been actively labelled ergosta-5,7,22,24(28)-tetraen-3fh12 (I ;

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