Augmented sensitivity to benzodiazepine in septic shock rats
than in both the control and the shamoperated groups, f3H]-diazepam radioligand binding assays demonstrated that the number of receptors in the septic rats was increased in the forebrain (CLP rats; control rats; cerebellum (CLP rats; control rats; and brain stem (CLP rats; control rats; compared with the control and shamoperated rats (P < 0.05). In conclusion, it was considered that th e increased number of benzodiazepine receptors may be one cause of the neuronal alteration observed in septic shock animals.
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