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Negative-ion fast-atom bombardment collision-induced dissociation tandem mass spectrometric (FAB-CID-MS/MS) methodology was successfully applied to verify the highly complex structure of ostreocin-D (MW 2633), a new palytoxin analog isolated from the marine dinoflagellate Ostreopsis siamensis and proposed to be 42-hydroxy-3,26-didemethyl-19,44-dideoxypalytoxin based on NMR data. The charge-remote fragmentations were facilitated by a negative charge introduced to a terminal amino group or to a hydroxyl group at the other terminus by a reaction with 2-sulfobenzoic acid cyclic anhydride. Product ions generated from the [M - H](-) ions provided information on the structural details of ostreocin-D. Comparisons between the spectral data for ostreocin-D and palytoxin also provided a rational basis for the assignments of product ions.

In order to enhance collaboration between food safety communities (industry, academia and government) and to ensure the safety of food, a new public network platform named Japan Food Safety Access Network (J -FSAN) has been in use since May 2021. Diverse food safety experts from different sectors, e.g., scientists, researchers of institutes, quality control managers of food industries and government officers, have been participating in J-FSAN. J-FSAN enables participants to share various information including domestic and international food safety trends, and directly discuss food safety issues. Consequently, J-FSAN will be beneficial to participants by reducing information gathering costs, and finding idea flows and different views. In digital transformation, J-FSAN will evolve into a more sophisticated tool as part of the digital government and change the work style of food safety policy-making in the future.