ABSTRACT:2,4-Di-O-benzyl-(1 ..... 6)-Il-D-glucopyranan, which was synthesized by ringopening polymerization of 1,6-anhydro-2,4-di-O-benzyl-3-0-tert-butyldimethylsilyI-P-D-glucopyranose and subsequent desilylation, was p-glucosylated or Il-mannosylated by the orthoester method. Deprotection of glycosylated polysaccharides with sodium in liquid ammonia was performed to give branched dextrans with free hydroxyl groups. Sulfation of the branched dextrans was carried out with piperidine N-sulfonic acid in dimethylsulfoxide to give new heparinoids. The Polymers were characterized by NMR spectroscopy, gel permeation chromatography, and optical rotation.KEY WORDS Ring-Opening Polymerization / Anhydrosugar / Branched Polysaccharide / Dextran / Sulfated Polysaccharide / Orthoester Method /
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