Antibiotics U 1200Synthesis of Novel Di-and Tricationic Carbapenems with Potent anti-MRSA Activity. -A benzyl moiety is introduced as a hydrophobic side chain at the 6-position of imidazothiazole in place of the carbamoylmethyl moiety of a recently discovered antimethicillin-resistant S.aureus β-lactam. These benzylated molecules show potent anti-MRSA activity but poor water solubility. The tricationic carbapenem (I) overcomes this drawback and exhibits excellent anti-MRSA activity and good water solubility. -(MARUYAMA*, T.; YAMAMOTO, Y.; KANO, Y.; KURAZONO, M.; SHITARA, E.; IWAMATSU, K.; ATSUMI, K.; Bioorg. Med.
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