Background: Factor C is autocatalytically activated on lipopolysaccharides. Results: The N-terminal Arg of factor C is essential for the autocatalytic activation.
Conclusion:The N-terminal Arg of factor C is required to be in sufficiently close vicinity for the autocatalytic activation. Significance: The recombinant factor C with restricted and homogeneous N-glycans may be useful for further structurefunction studies.
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