Objective: To assess relative comparison of stability and degradation of Methylcobalamin tablets of different brands at various storage circumstances. Methods: The comparative in vitro study of Methycobal (innovator brand) with its other 5 different brands Cobalamin, Neuromet, Incobal, Qbal and Mecobal was organized for evaluation of physicochemical features of hardness, thickness, friability, weight variation, disintegration time and accelerated stability at 3 temperatures, 25 °C, 30 °C±65 % and 40 °C±75 % respectively for 3 mo. Later all brands were passed through HPLC for checking the extent of degradation of drug products. Results: All tablet brands were within the weight variation specified limits except Mecobal with a relative standard deviation of 6.83%. The weight variation values of Methycobal, Cobalamin, Neuromet, Incobal, Qbal and Mecobal were 0.29%, 0.11%, 0.09%, 0.13%, 0.09% and 0.14% after friability test respectively as per standard limits. The average thickness of Cobalamin, Incobal and Mecobal were not within specified limits. The average hardness of all trades was within limits except Cobalamin and Mecobal exceeding 6kp. The disintegration time of all companies was as per specifications. Conclusion: Qbal was found economical and cost-effective. However, study facts unveiled no noteworthy variety in the Q. C assessments of Methylcobalamin brands.
Traditionally, ivy leaf (Hedera helix) has been used for a large number of ailments. In the 19th century, water-based extract of young leaves was used for respiratory diseases. The aim of the current study was to quantify the triterpene saponin named hederacoside C of ivy leaf spray-dried extract of Hedera helix using high-performance liquid chromatography (HPLC) method coupled with UV-visible detector. The solvent system consisted of solvent A (phosphoric Acid 85%: acetonitrile: water with the ratio of 2: 140: 860) and solvent B (phosphoric acid 85%: acetonitrile with the ratio of 2:998). A gradient elution was used for separation at 205 nm at a flow rate of 1.5 mL/min. The separation was performed using a C18 column at a temperature of 40°C. The method was validated as per ICH guidelines for precision, accuracy, recovery, ruggedness, and robustness. The method was found to be precise, accurate, robust, and reproducible according to the guidelines of United States Pharmacopeia 2014 and European Pharmacopeia 8.0. The content of triterpene saponins was found to be 17.6%. Despite many studies reported on the method development and quantification of compounds of Hedera helix, there is insufficient work reported on the spray-dried extracts of this plant. This study quantifies the hederacoside C from the spray-dried extract of the plant by developing an accurate, cheap, robust, and precise method. The proposed method can be of significant usage in the pharmaceutical industry.
The aim of this study was to formulate and evaluate bisoprolol hemifumarate emulgel using carbopol 934P with the enhancers, thymus oil and olive oil. Thymus oil and olive oil were used as permeation enhancers. The emulsion formulations were added to a base gel. The emulgel was characterized for physical characteristics, stability, skin irritation, and drug release. Formulations F1 and F5 indicated the best in-vitro drug release when compared with other preparations. Bisoprolol hemifumarate emulgel containing carbopol 934P and thymus oil or olive oil enhancers could be further developed for a topical drug delivery system.
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