Introduction: The outcomes of Catheter Ablation (CA) and antiarrhythmic drugs (AAD) as the first-line treatment of paroxysmal Atrial Fibrillation (AF) are unclear. The current systematic review reports the evidence on efficacy outcomes of Radiofrequency Ablation (RFA) versus antiarrhythmic drugs (AAD) among these patients. Methods: Three databases, including PubMed, Cochrane, and Google Scholar, were searched by three independent reviewers to identify relevant randomized control trials (RCTs). Results: A total of 1,145 patients across five studies were assessed in this systematic review. Among these patients, 577 were randomized to receive ablation, and 568 were randomized to receive AAD. The recurrence rate was significantly higher among patients who received AAD at 1-year and 2-year follow-ups. The health-related quality of life (HR-QoL) was significantly better in the patients who received ablation therapy. The incidence of serious adverse events was 14 (6.4%) in the ablation group and 9 (4.3%) in the AAD group. Conclusion: CA seems promising for managing AF in terms of any AF recurrence, hospitalization, and quality of life. There was no increase in side effects compared to AAD.

To improve medication adherence in hypertensive patients. Methods and materials: This cross-sectional observational research was conducted among participants with hypertension who had been on therapy for the previous 12 months were recruited for the trial after providing written informed permission. A full history was obtained, and the subjects were subjected to a thorough clinical evaluation, as well as counselling for lifestyle changes. The patients were given the MO risky Medication Adherence Scale-8 (MMAS-8) and WHO-QOL Brief questionnaires, and they were given time to complete them in a separate room away from the treating physician. Results:The average age of the patients was 53.98±10.78 years, the average number of medications taken per individual was 1.82±0.79, and 74% of the patients were using a combination of pharmaceuticals for hypertension. The mean MMAS-8 Score of 4.52±1.22 and the mean WHO-QOL Brief Scores. The mean duration of illness in Group 1 was substantially (p0.05) smaller than in Group 2 (4.41±2.52 years vs. 5.51±2.81 years), and the MMAS-8 scores in Group 1 were significantly (p<0.05) higher (4.81±1.42 vs. 3.79±0.76)patients in Group 1 were more adherent to treatment than patients in Group 2. Group 1 had better scores in three domains: physical health (12.12±1.42 vs. 12.11±1.42), social connection (13.54±4.25 vs. 12.89±4.52), and environment (12.02±1.28 vs. 12.06±1.47), but Group 2 had higher scores in one domain: psychological (13.11±2.36 vs. 12.95±2.41). Because the surveys were only to be filled out by patients, there was a risk of interpretation bias based on the patients' comprehension. Conclusion: To summarise, patients had a poor adherence score, which was considerably lower in patients who were taking two or more drugs in combination or as a single component.

The purpose of this research is to assess the antibiotic prescription analysis of inpatients at a tertiary care hospital. Methods: The Department of Pharmacology conducted this prospective investigation. We examined the source of information for relevant features such as antimicrobial dose, frequency, and duration of antimicrobial usage, as well as whether or not such use was indicated by recorded culture sensitivity reports. A possible infective aetiology was evaluated if the patient showed any of the following symptoms prior to study inclusion: fever, elevated leukocyte count, signs and symptoms of infection of a specific organ system, and sepsis. Results: Antimicrobials were prescribed to 100 (43.48 percent) of the 230 patients. The referral note was the most often utilised source for obtaining information on antibiotic prescription. The prescription habits of these individuals were studied further. 59 patients (59%) were males, whereas 41 patients (41% were women). The research participants' mean (SD) age was 48.25 12.55 years. The most patients were between the ages of 35 and 45. (40 percent). 58 patients (58%) were recommended by public sector healthcare facilities, whereas 42 (42%) were referred by private clinics. Ceftriaxone and amoxicillin-clavulanic acid were the most often given medications (21 percent and 17 percent, respectively). Piperacillin-tazobactam was then administered to 12 (12%) of the patients. More than 57 percent of patients were given four antibiotics. Antibiotics with a broad range of action accounted for 70 percent of prescriptions. Conclusion:The results of this research aided in the development of several modules of an educational intervention tailored for healthcare settings with limited or no access to antimicrobial stewardship training.