We evaluated a commercial immunoglobulin M (IgM)-capture immunoassay for the detection of Mycoplasma pneumoniaeinfections in 278 pediatric patients with community-acquired, radiographically defined pneumonia. Acute- and convalescent-phase serum samples were collected from all patients and were tested for M. pneumoniae-specific IgM and IgG antibodies by Platelia enzyme immunoassays (Sanofi Diagnostica Pasteur, Marnes la Coquette, France). Nasopharyngeal aspirates (NPAs) were collected at the time of admission to the hospital. A total of 227 NPAs were subjected to the detection ofM. pneumoniae DNA by PCR, and 191 NPAs were cultured by using the Pneumofast kit (International Mycoplasma, Signeswere, France). Southern hybridization of PCR products and the IgM test with solid-phase antigen (Serion Immunodiagnostica, Würzburg, Germany) were used for additional confirmation of a positive result, which required agreement of at least two different methods. A total of 24 (9%) confirmed diagnoses of mycoplasma infection were made, 5 (21%) of which were in children <5 years of age. Of the positive children, 24 of 24 (sensitivity, 100%) were positive by the IgM-capture test with convalescent-phase serum, 19 of 24 (79%) were positive by the IgM-capture test with acute-phase serum, 19 of 24 (79%) were positive by IgG serology, 10 of 20 (50%) were positive by PCR, and 8 of 17 (47%) were positive by culture. An additional 5 (of 254) children were positive by the Platelia IgM test alone (specificity, 98%). When the PCR with Southern hybridization result was combined with the IgM-capture test result with the acute-phase sera, the sensitivity of rapid laboratory diagnosis increased to 95%. In conclusion, the IgM serology test was the single most valuable tool for the diagnosis ofM. pneumoniae pneumonia in children of any age.

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English-medium instruction at university worldwide:Challenges and ways forward eds. Aintzane Doiz, David Lasagabaster, Juan Manuel Sierra (Multilingual Matters)

Finland is among the countries with the highest amount of English-taught programmes in higher education in Europe (Wächter and Maiworm 2008). This article analyses, how the higher education language situation of a small country with a marginal majority language (Finnish) and an official bilingual status (Finnish and Swedish) has historically developed from the setting of "drawing the line" between Finland and Sweden or Finland and Russia (Harle and Moisio 2000) in the 19th century and the early 20th century (nationalism), towards drawing the line between Finnish/Swedish and English in the late 20th century (globalization). It then continues to present a case of foreign language (in practice English) programmes in higher education as an example of the globalization development in Finnish higher education. The data for the article consists of the internationalization strategies for Finnish higher education, The Finnish International Study Programme Database, and introductory texts from four universities' and four polytechnics' International BA and MA programmes.

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