Background With the ongoing coronavirus (COVID-19) pandemic, evaluating the incidence of infection in major health centers and assessing the employed protocols is necessary for the management of the disease. Aim Since Shiraz Transplant Center is one of the major transplant centers in Iran and the Middle East, this study was conducted to evaluate outcomes of the applied policies on COVID-19 disease detection and management. Methods During 4 months from March to June, patient's data diagnosed with the impression of COVID-19 were extracted and evaluated based on demographic and clinical features, along with the length of hospital stay and expenses. Findings: Our data demonstrated that a total of 190 individuals, with a median age of 58, were diagnosed with COVID-19 during the mentioned period. Among these, 21 patients had a positive PCR test and 56 patients had clinical symptoms in favor of COVID-19. Also, 113 (59%) patients were classified as mild based on clinical evidence and were treated on an outpatient basis. Furthermore, 81 out of 450 cases (18%) of the healthcare workers at our center had either PCR of clinical features in favor of COVID-19. The mortality rate of our study was 11% and diabetes mellitus, hypertension were considered risk factors for obtaining COVID-19 infection Conclusion Based on the reported data, our transplant center was able to provide early detection for COVID-19 and apply necessary treatment and prevention protocols to safeguard the patients under its coverage.