Immediately after heart valve replacement, patients are more sensitive to warfarin and should receive a lower warfarin dose during the initial phase of oral anticoagulation treatment. This enhanced sensitivity decreases with time. Patients require frequent monitoring and are likely to need an increase in the warfarin dose to avoid insufficient anticoagulation during the early follow-up period.
Costs 2001/2'' www.show.scot.nhs.uk/isd/. 19 National Institute for Health and Clinical Excellence. Guidance on coronary artery stents in the treatment of ischaemic heart disease (May 2000). www.nice.org.uk/page.aspx?0 = 898851/. 20 Sculpher MJ, Petticrew M, Kelland JL, et al. Resource allocation for chronic stable angina: a systematic review of effectiveness, costs and cost-effectiveness of alternative interventions.
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