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Background: Schizophrenia is one of the most serious and debilitating psychiatric disorders. that cause basic changes within the human brain. Objective: to evaluate MRI brain changes in patients with psychotic disordersMethodology: This cross sectional study was conducted on 50 patients aged from 15-40 years of both sexes. The patients were recruited from Al-Azhar University hospitals all of them were applied to Complete psychiatric history and examination, Structured Clinical Interview for DSM-IV (SCID-I), Positive and Negative Syndrome Scale(PANSS), Wechsler Adult Intelligence Scale, Brain magnetic resonance imaging. Results:In the current study, MRI brain changes among the studied group were 40%.There was also no measurable critical relationship (p-value > 0.05) between MRI results and the following parameters (age, positive scale, general scale, duration of disease and duration of treatment). Statistically significant correlation(p-value < 0.05) between MRI brain results and negative scale and total PANSS was present. Conclusion:There is a relation between psychotic disorders such as schizophrenia and MRI brain changes. Patients with negative symptom are more inclined to have brain changes. Antipsychotic medication has no role in brain changes in schizophrenia with no difference between first generation antipsychotic and second generation antipsychotic.

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