In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded
paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the
tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid
(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated
with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,
LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated
endocytosis.
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