The Medpor porous polyethylene implant is a highly stable and somewhat flexible porous alloplast that has been shown to exhibit rapid tissue ingrowth into its pores. A total of 116 Medpor implants were placed in 70 patients over a four-year period. Implants were used for the chin, malar area, nasal reconstruction, ear reconstruction, orbital reconstruction, and the correction of craniofacial contour deformities. Many of these implants were placed in areas long considered problematic such as areas of thin soft tissue coverage, extensive scarring, and severe facial burns. Nine complications occurred including seven exposures, all of which occurred in areas of minimal soft tissue coverage. Because of the rapid vascularization of the implants, only two implants were removed, both from the columella. On the basis of our results, it is felt that the Medpor implant is an excellent alternative to existing implant materials. The implant is easy to shape; it is strong yet somewhat flexible; it is remarkably stable; and it exhibits tissue ingrowth into its pores.
Traditional formulations of bone wax are composed largely of beeswax and are well known to interfere with bone healing and cause inflammatory reactions. Ostene, a newly available bone hemostasis agent made of water-soluble alkylene oxide copolymers, was evaluated. The soft tissue response to Ostene was compared with bone wax and a polyethylene control after implantation into the paravertebral muscles of three rabbits. After 2 weeks, Ostene elicited no fibrous response, the polyethylene elicited a thin (less than 0.5 mm) fibrous response, and the bone wax was encased in a fibrous capsule 0.6 to 1.0 mm thick infiltrated with inflammatory cells. The effects of Ostene were compared with bone wax in a femur defect model in eight rabbits. Ostene showed no evidence of an adverse response in the cortical defect site, medullary cavity, or the surrounding tissue at 4 and 8 weeks. In contrast, bone wax at both time intervals elicited a foreign body response consisting of fibrous tissue infiltrated by macrophages, giant cells, and lymphocytes at the sites of the bone defects. Bone wax also displaced the bone marrow and interfered with bone ingrowth into the defects. Ostene provides the clinician a water-soluble bone hemostasis material that does not demonstrate the adverse tissue response or the interference with bone healing seen with the use of bone wax.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.