These results are useful for understanding the molecular basis of the mechanisms of CRSwNP and point to new targets for developing specific biomarkers and personalized therapeutic strategies for CRSwNP.

No abstract

Forward spinal inclination was associated with impairment in various physical performance measures. Proper prevention and treatment of underlying disorders should be prompted.

Purpose This study aimed to evaluate the 10-year adherence to and identify the predictors of dropout from continuous positive airway pressure (CPAP) treatment for patients with moderate-to-severe obstructive sleep apnea (OSA). Methods We retrospectively analyzed the continuity, dropout, or other behaviors of 181 patients who initiated CPAP treatment at the Tokyo Dental College Ichikawa General Hospital from January 2003 to June 2005. Results Among a total of 181 patients, 56 (30.9%) dropped out of the treatment. Among the 125 patients who did not dropout, 54 continued CPAP treatment for > 10 years, 16 completed the treatment with OSA improvement, and 7 could not complete the treatment owing to unavoidable reasons such as death, dementia, hospitalization for serious illness, or migration to other countries. Further, 47 patients moved to another facility, whereas 1 patient purchased a CPAP device and stopped visiting our facility. Among the 56 patients who dropped out, approximately 50% of the patients dropped out within a year, and all dropped out within 76 months. Comparing demographics, OSA parameters, and CPAP parameters between the patients who did and did not drop out of the treatment, Cox regression analysis indicated that body mass index (BMI) and the first-month utilization rate were clinical variables that were independently associated with discontinuation of CPAP treatment.Conclusion The results of this study show that BMI and the first-month utilization rate of CPAP treatment are the predictors of the long-term adherence to this treatment.

This study demonstrates that ADAMDEC1 is involved in the pathogenesis of NECRSwNP, and also bacterial endotoxin signalling in macrophages; however, the underlying mechanism remains to be elucidated.

No abstract

In endoscopic endonasal sinus surgery for postoperative a maxillary mucocele, draping a mucosal flap over the bony border of the opened mucocele is important to prevent stenosis or closure. The mucosa of the inferior meatus is often used to drape the bony edge of a mucocele adjacent to the inferior meatus. However, the mucosal flap cannot be applied to a mucocele adjacent to the nasolacrimal duct. Therefore, we utilized the nasolacrimal duct as a mucosal flap to drape over the bony edge in cases with an opened mucocele adjacent to the nasolacrimal duct. We present one case and demonstrate the nasolacrimal duct flap technique. Furthermore, we describe the postoperative course of four consecutive subjects who underwent surgery with use of the nasolacrimal duct flap technique. In all four subjects, no lacrimation or epiphora was observed and the patency of the mucoceles was confirmed during the follow−up period. The nasolacrimal duct flap as a mucosal flap to cover the edge of the mucocele adjacent to the nasolacrimal duct not only prevented stenosis or closure, but also created a drainage pathway through the inside of the nasolacrimal duct, without posing an obstacle to the nasolacrimal drainage system.