The block glycopolymer, poly(2-(a-D-mannopyranosyloxy)ethyl methacrylate)-b-poly(L-lactide) (PManEMA-b-PLLA), was synthesized via a coupling approach. PLLA having an ethynyl group was successfully synthesized via ring-opening polymerization using 2-propyn-1-ol as an initiator. The ethynyl functionality of the resulting polymer was confirmed by MALDI-TOF mass spectroscopy. In contrast, PManEMA having an azide group was prepared via AGET ATRP using 2azidopropyl 2-bromo-2-methylpropanoate as an initiator. The azide functionality of the resulting polymer was confirmed by IR spectroscopy. The Cu(I)-catalyzed 1,3-dipolar cycloaddition between PLLA and PManEMA was performed to afford PMa-nEMA-b-PLLA. The block structure was confirmed by 1 H NMR spectroscopy and size exclusion chromatography. The aggregating properties of the block glycopolymer, PManEMA 16k -b-PLLA 6.4k (M n,PManEMA 5 16,000, M n,PLLA 5 6400) was examined by 1 H NMR spectroscopy, fluorometry using pyrene, and dynamic light scattering. The block glycopolymer formed complicated aggregates at concentrations above 21 mgÁL 21 in water. The D-mannose presenting property of the aggregates was also characterized by turbidimetric assay using concanavalin A.
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