We examine if cell adhesion to the surface of an intraocular lens varies with the period of implantation. Samples of extracted intraocular lenses (IOLs) that had been implanted during 1987-2000 (n=72, early group) and those during 2001-2014 (n=182, late group) were included. IOLs were stained with hematoxylin and eosin and grouped according to the presence or absence of cellular deposits on the central area of the IOL anterior surface. Silicone IOLs were excluded because the silicone material does not adhere to cells. The early group included four poly( ethyl methacrylate) (PEMA) IOLs, 45 poly (methyl methacrylate) (PMMA) IOLs, and 23 acryl IOLs, and the late group included four PEMA IOLs, 19 PMMA IOLs, 152 acrylic IOLs, and seven hydrogel IOLs. Twenty-six of 72 samples (36%) in the early group and 43 of 182 IOLs (23%) in the late group were associated with cellular deposits in the central area of the IOL surface. The difference was statistically significant using the chi-square test. The number of IOLs with cell adhesions was less in the late group when compared with the early group.
We herein present a case of congenital erythrocytosis caused by haemoglobin (Hb) Bethesda in a Japanese family. A 55-year-old asymptomatic man was referred to our hospital for the investigation of erythrocytosis, which was present in other members of his family. The patient's serum erythropoietin level was normal, and the JAK2 V617F mutation was not detected. His P50 value was mildly decreased, thus we suspected the presence of an Hb variant with a high oxygen affinity. The high-performance liquid chromatography analysis showed an abnormal Hb, and by direct sequencing we identified the Hb Bethesda variant in this patient. For the differential diagnosis, we recommend the estimation of the P50 value as a practical and useful test.
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