When administered orally to male rats at 1.6 to 4.8 mg/kg, the [1R,trans], [IRS,trans], [lR.cis], and [IRS,cis] isomers of the potent pyrethroid insecticide permethrin [3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate] are rapidly metabolized, and the acid and alcohol fragments are almost completely eliminated from the body within a few days. cis-Permethrin is more stable than trans-permethrin and the cis compound yields four fecal ester metabolites which result from hydroxylation

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