Background:
Selenium is a micronutrient although required in low amounts but its importance in male and
female reproduction is well known.
Objectives:
The core purpose of this study is to evaluate the role of selenium in human reproduction, during
pregnancy/ lactation in women and newborns. The review explains side by side the sources of
selenium, required amounts of selenium in humans and during pregnancy or lactation.
Methods:
Selenium deficiency is a major cause of male infertility. Similarly selenium deficiency both in
pregnant and postpartum women would greatly affect the health of newborn baby in all respects.
The effect of maternal selenium upon the fetus and the neonates even one year after birth has
been explained with some recent examples.
Results:
The study elaborates the fact that the selenium deficiency in pregnancy and lactation is common
due to fetal/infant development so selenium supplements must be provided in order to overcome
these deficiency symptoms.
Conclusions:
The better reproductive health in humans is possible due to the sufficient amounts of selenium
present both in males and females as well.
A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C 2 H 4 NO 2 ) 2 (H 2 O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P2 1 2 1 2 1 space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.
Three new nano-bioMOFs (NBMOFs) (copper serinate, copper prolinate, and copper threoninate) have been hydrothermally synthesized and characterized by the scanning electron microscopy (SEM). Molecular masses of these nanomaterials have been obtained by mass spectrometric studies. Successfulin vitrodrug adsorption of rosuvastatin drug has been carried out in these three nanosized materials. The amount of rosuvastatin adsorbed in these materials and its slow release after intervals have been monitored by the high performance liquid chromatography (HPLC). TGA and PXRD spectra of all these materials in pure form and after rosuvastatin adsorption have also been recorded to elaborate the phenomenon ofin vitrodrug adsorption in these materials.
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