Background
American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis.
Methods
A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients.
Results
The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023).
Conclusions
This study adds to the body of knowledge on differences that exist between different age groups in ATL.
Objectives: This study aimed to evaluate the validity and reliability of HINT-8, a generic health-related quality of life (HRQOL) instrument, in breast cancer patients after surgery. Methods: Three hundred breast cancer patients who were admitted for surgery or who visited the outpatient clinic for postoperative follow-up at a tertiary hospital in South Korea were provided with self-administered HRQOL measurement instruments including HINT-8, EQ-5D-5L, EQ VAS, and FACT-B. Known group validity was assessed across a range of demographic features and clinical characteristics related to breast cancer. The discriminatory ability of the HINT-8 was determined by comparing mean scores of HRQOL instruments between groups with (mild/moderate/severe problems) and without problems (no problems), considering the level of severity of HINT-8 items. Construct validity was evaluated by Pearson correlation coefficients among the HINT-8 index and FACT-B subscales, respectively. Test-retest reliability was assessed by using Cohen's kappa value and intra-class correlation coefficient (ICC). Results: HINT-8 index was lower in groups with older age, lower education, lower income, and comorbidities. Patients with no problems in each item of the HINT-8 showed significantly higher scores than subjects with problems in EQ-5D-5L index (p,0.01) and EQ VAS (p,0.01). In subjects without problems on the HINT-8, FACT-B subscale scores were also higher, as were FACT-G (general), FACT-Total, and trial outcome index. The Pearson correlation coefficients of HINT-8 index with EQ-5D-5L index and EQ VAS were 0.671 (p,0.01) and 0.577 (p,0.01), respectively. The correlation between the HINT-8 and the FACT-B subscales was highest in physical well-being (r=0.714, p,0.01) and lowest in social well-being (r=0.390, p,0.01). Kappa values of the HINT-8 ranged from 0.249 to 0.513; the ICC was 0.690
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.