The present work continues to investigate the physicochemical characteristics of CeF3 nanopowder (NP) produced using the method of pulsed electron beam evaporation (PEBE) in vacuum. The resulting NP was isothermally annealed in air at the temperature of 200, 300 and 500 °C for 30 minutes. XRD showed that the cubic phase CeO2 formed in NP CeF3after annealing at the temperature of 500 °C. The intensity of photoluminescence of NP CeF3 decreased non-monotonically with an increase in the annealing temperature, the appearance of the oxide phase CeO2led to an increase in the intensity of photoluminescence. The paramagnetic response of the NP decreased after annealing. The addition of not annealed NP CeF3 to tumor culture HeLa and non-neoplastic Vero culture resulted in a 20–35% reduction in cell viability at all NP concentrations in the aqueous suspension. The obtained data show the low cytotoxicity of NP CeF3to tumor and non-tumor cells. Improved texture parameters indicate the prospect of using CeF3 as a nanocontainer to deliver various dosage forms in biomedicine.
This paper presents the physicochemical characteristics of CeF3 nanopowder (NP) obtained via electron evaporation. The initial NP was annealed in air (200–500 °C) for 30 min. The annealed NP was evaluated using the following methods: X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), differential scanning calorimetry-thermogravimetry (DSC-TG) and luminescence/magnetic measurements. The degree of cytotoxicity of CeF3 nanoparticles (NPles) to cell cultures was determined. The cubic phase CeO2 formed in CeF3 NP after annealing (500 °C). The appearance of the CeO2 oxide phase led to an increase in the intensity of photoluminescence. Cathodoluminescence was not excited. The paramagnetic response of NPles decreased with an increase in the annealing temperature. Cerium fluoride NPles showed low cytotoxicity towards cancerous and non-cancerous cells. Annealing of the CeF3 NP at low temperatures led to an improvement in the textural parameters of the not annealed NP. Improved texture parameters indicate the prospect of using CeF3 as a biomedicine nanocontainer.
Was carried out the assessment of photocatalytic, cytotoxic properties on cells and antibacterial properties against E. coli and Staphylococcus of oxides nanopowders with nanoscale silver coating. Is shown the promising use of such composites as a photocatalytic agent, as well as in medicine.
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