Aims-To assess changes in incidence of conjunctival squamous cell carcinoma over a 22 year period in Tanzania and to analyse possible reasons for change. Methods-Retrospectiveanalysis of records from a Tanzanian pathology department serving north and central Tanzania from 1976 to 1997; medical record analysis of cases of conjunctival squamous cell carcinoma presenting in the last 2 years of the study. Results-There was a sharp rise in the incidence of conjunctival squamous cell carcinoma in the last 3 years of the study (1995-7). The mean age of patients presenting with the condition over the full period was 44.7 years (95% confidence interval 42.4-46.9 years). In the final 2 years of the study the mean length of history on presentation was 3

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Thirty-two inbred Wistar rats (study group) were exposed to trichloroethylene 100 p.p.m. in air for 4 h daily from day 8 to day 21 of pregnancy. A control group (31 rats) was exposed to the same experimental conditions but without the addition of trichloroethylene. All the rats were sacrificed on the 21st day of pregnancy and the ovaries, uterus, liver, lungs, heart and the fetuses were examined. There was no evidence of teratogenesis, but a delay in fetal maturation was suggested by reduced fetal weight (P less than 0.05) and by an increase in bipartite or absent skeletal ossification centres (P less than 0.005).

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