A new reaction cascade to give tricyclic cores of 2,4‐dihydro‐1H‐azeto[1,2‐a]quinolines (benzocarbacephems) and pyrrolo[1,2‐a]quinolines starting from acyclic N‐aryl ketonitrones and acceptor ring substituted methylenecyclopropanes has been reported. This reaction includes 1,3‐dipolar cycloaddition of N‐aryl‐C,C‐diaryl or N‐aryl‐C,C‐bis(methoxycarbonyl) nitrones 1 to the double bond of dimethyl methylenecyclopropane‐1,2‐dicarboxylate 2 or benzylidenecyclopropane‐1,1‐dicarboxylate 3, followed by Brandi–Guarna rearrangement of the initially formed 5‐spirocyclopropane‐isoxazolidine cycloadducts to give 2,4‐dihydro‐1H‐azeto[1,2‐a]quinolines 4 or pyrrolo[1,2‐a]quinolines 6.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.