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Among this cohort, all cases of unsuspected UM at the time of myomectomy or hysterectomy using power morcellation were found to be endometrial carcinoma. Unsuspected UM pathology had an incidence of 1 of 502. Factors associated with increased likelihood of UM or UPM were greater uterine weight and leiomyoma as the surgical indication.

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decreased cell viability and induced DNA damage by an increase in pH2AX in ovarian cancer cells. ATRi with ATRIN119 had similar antiproliferative effects to PARPi in BRCA-mutant ovarian cancer cells. ATRIN119 had antitumor effects with minimal toxicity using a novel BRCA2-mutant patient-derived xenograft (PDX) model supporting a possible synthetic lethality mechanism. Conclusions: Strategies to optimize approaches capitalizing on synthetic lethality in HR-deficient ovarian cancers are needed. ATR inhibition with ATRIN119 is a viable therapeutic option and further preclinical work is ongoing to optimize bioavailability and to identify the maximum tolerated dose.