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SummaryIn these investigations it was shown that the contact factors of the coagulation system - isolated as in the contact activation test according to Egli or as Celite eluate (Waaler) - do not influence platelet aggregation. Platelet aggregation was measured by the rotation method of Wright.It was concluded that contact of blood with wettable surfaces leads to activation of the coagulation system and independently to aggregation of platelets. By heating of plasma to 56° a platelet aggregating principle is liberated; the significance of this finding needs further investigation.

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SummaryRabbits were treated in 3 groups : Group A received 20 ml/kg Lipofundin, group B received 150 mg/kg india ink and 20 ml/kg Lipofundin, group C received 150 mg/kg india ink and 20 ml/kg isotonic glucose. Group A and B showed a decrease of activity of the factors II, V, VII, serumcomplex and a decrease of the platelet count. The changes were more pronounced in group B and 6 of 8 animals of this group died after the infusion. In group A only 1 animal died. All controll animals (group C) survived. There were no significant changes in the coagulation system in group C. The contact factors showed an activation in group B, little activation in group A and inconsistent activation in group C. In vitro india ink was able to produce a moderate activation of the contact system. The high death rate after administration of india ink and fat is thought to be due to a consumptive coagulopathy.