Background: Brown recluse spider bites are a serious medical problem in the southeastern United States. Although most bites are asymptomatic, envenomation can result in a constellation of systemic symptoms referred to as loxoscelism. Patients can also develop necrotic skin ulcers (necrotic arachnidism). These ulcers are often difficult to heal and can require skin grafting or amputation of the bitten appendage.Metbods: A search of the literature was performed using the search words "spider envenomation," "brown recluse spider bites," and "arachnid envenomation."Results and Conclusions: Most brown recluse spider bites are asymptomatic. All bites should be
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