Atypical neuroleptics produce fewer extrapyramidal side-e ects (EPS) than typical neuroleptics. The pharmacological pro®le of atypical neuroleptics is that they have equivalent or higher antagonist a nity for 5-HT 2 than for dopamine D 2 receptors. Our aim was to identify which 5-HT 2 receptor contributed to the atypical pro®le. Catalepsy was de®ned as rats remaining immobile over a horizontal metal bar for at least 30 s, 90 min after dosing.
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