Background: Deficiencies in -D-galactosidase cause lysosomal storage diseases. Results: This is the first report to describe the crystal structure of human -Gal. Human -Gal is composed of a TIM barrel domain and two -domains. Conclusion: The mutations were classified as mutations directly affecting the ligand recognition, mutations inside the protein core, or mutations located in the protein surface. Significance: Structural insights into lysosomal storage diseases mutations can be demonstrated.
KAGRA is a second-generation interferometric gravitational-wave detector with 3 km arms constructed at Kamioka, Gifu, Japan. It is now in its final installation phase, which we call bKAGRA (baseline KAGRA), with scientific observations expected to begin in late 2019. One of the advantages of KAGRA is its underground location of at least 200 m below the ground surface, which reduces seismic motion at low frequencies and increases the stability of the detector. Another advantage is that it cools down the sapphire test mass mirrors to cryogenic temperatures to reduce thermal noise. In April-May 2018, we operated a 3 km Michelson interferometer with a cryogenic test mass for 10 d, which was the first time that km-scale interferometer was operated at cryogenic temperatures. In this article, we report the results of this 'bKAGRA Phase 1' operation. We have demonstrated the feasibility of 3 km interferometer alignment and control with cryogenic mirrors.
KAGRA is a 3-km interferometric gravitational wave telescope located in the Kamioka mine in Japan. It is the first km-class gravitational wave telescope constructed underground to reduce seismic noise, and the first km-class telescope to use cryogenic cooling of test masses to reduce thermal noise. The construction of the infrastructure to house the interferometer in the tunnel, and the initial phase operation of the interferometer with a simple 3-km Michelson configuration have been completed. The first cryogenic operation is expected in 2018, and the observing runs with a full interferometer are expected in 2020s. The basic interferometer configuration and the current status of KAGRA are described.
We apply independent component analysis (ICA) to real data from a gravitational wave detector for the first time. Specifically, we use the iKAGRA data taken in April 2016, and calculate the correlations between the gravitational wave strain channel and 35 physical environmental channels. Using a couple of seismic channels which are found to be strongly correlated with the strain, we perform ICA. Injecting a sinusoidal continuous signal in the strain channel, we find that ICA recovers correct parameters with enhanced signal-to-noise ratio, which demonstrates the usefulness of this method. Among the two implementations of ICA used here, we find the correlation method yields the optimal results for the case of environmental noise acting on the strain channel linearly.
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