Simple methods for oxidimetric determination of antibiotic Cefuroxime in the substance and in the powder for solution for injection, which are based on the S-oxidation reaction by potassium hydrogenperoxomonosulphate in a weak acidic medium to S-oxide withThe aim of the study was to develop a new method for quantitative determination of cefuroxime in the substance and the powder for solution for injection by oxidimetry using potassium hydrogenperoxomonosulphate as an analytical reagent (KHSO 5 ).
Materials and MethodsA triple potassium salt of Caro's acid, 2KHSO 5 •KHSO 4 • K 2 SO 4 (the trade name -"Oxon ® " manufactured by DuPont), was used as an oxidising agent. The active substance is potassium hydrogenperoxomonosulphate, KHSO 5 . The choice of the reagent was determined by its rather high oxidative activity, Е 0 = 1.84 V, availability, and satisfactory solubility in water.
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