Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5'-Protecting Group Bearing an Imidazole Residue.-A new approach to the stereocontrolled formation of internucleotidic phosphorothioate triester bonds by use of a modified trityl group (Idtr) as the 5'-hydroxyl protecting group in the phosphotriester approach is described. -(WADA, T.; KOBAYASHI, N.; MORI, T.; SEKINE, M.; Nucleosides Nucleotides 17 (1998) 1-3, 351-364; Dep. Life Chem., Tokyo Inst. Technol., Midori, Yokohama 226, Japan; EN)
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Diastereo-and Enantioselective Synthesis of Allylsilane. A Useful C-Ring Fragment of Taxol.-Starting with the diastereoselective (4 + 2) cycloaddition of the pyrone (I) with ether (II) a stereoselective synthesis of the allylsilane taxol C-ring fragment (VII) is achieved. Key feature of the synthesis is the conversion of cyclohexenyl sulfides (V) and (VIII) to the same title compound by treating with LDBB followed by quenching with Tms-Cl. -(KUSAMA, H.; MORI, T.; MITANI, I.; KASHIMA, H.; KUWAJIMA, I.; Tetrahedron Lett. 38 (1997) 23, 4129-4132; Dep. Chem. Eng., Tokyo Inst. Technol., Meguro, Tokyo 152, Japan; EN)
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