Objective: Correlations between corpus callosum size and interhemispheric EEG coherence were investigated as measures of interhemispheric connectivity in patients with Alzheimer's disease. Methods: 11 patients underwent both magnetic resonance imaging and quantitative electroencephalography to assess corpus callosum size and interhemispheric coherence. For comparison, corpus callosum size was measured in 24 healthy elderly control subjects. Results: Corpus callosum cross sectional area was significantly reduced in Alzheimer patients relative to controls. Posterior interhemispheric coherence (a and b frequencies) correlated significantly with the size of posterior corpus callosum area, and anterior coherence (d, h, and a frequencies) with the size of anterior corpus callosum area in the Alzheimer patients. Conclusion: Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum.
In the frame of a pre-experimental study 104 male patients aged 65,7 ± 5,5 years suffering asbestosis carried out over a period of three weeks 5 times weekly 6 h at a time phase 1 of the OMR consisting of evidence-based contents of the pulmonary rehabilitation. Directly after that further therapeutic applications with the main focus on exercise therapy and sports were applied over a period of 12 weeks one time weekly 3 h at a time (phase 2). After phase 2 the rehabilitation centre led the patients into sports groups near at place of residence (phase 3). The effects of the OMR were evaluated at the beginning (T1), at the end of phase 1 (T2) and phase 2 (T3) as well as 6 (T4) and 18 months (T5) after T3 by means of a suitable assessment.Results: Compared to T1 physical fitness (6-minute Walk Test, Hand-Force Test, PWC Test) as well as health-related quality of life (SF-36) of the patients were significantly improved in T2. Whereas the parameter "vital capacity" and "forced expiratory volume" showed no change over the period of investigation data of "oxygen partial pressure" was significantly increased, too. These positive effects could be confirmed in T3. 82 patients (79 %) were doing sports due to health regularly still 6 and 18 months after T3 and could preserve their health outcome in T4 and T5, while the effects of rehabilitation of the 22 patients breaking off any sporting activities wore off again to and even below starting condition in T1.Conclusions: In spite of a restrictive pulmonary disease specific exercise therapy and sports are able to mobilize physical reserves of performance
In spite of a restrictive pulmonary disease, specific exercise therapy and sports are able to mobilize physical reserves of performance and induce an increasing quality of life as well as a higher resilience in activities of daily living. These positive effects could be stabilized persistently by a regular training once a week. Thus, the results emphasize the necessity to include strategies of aftercare in the concept of rehabilitation.
<p>The construction of offshore wind farms in Germany's Exclusive Economic Zone (EEZ) is an important component for the successful implementation of the energy transition. In 2021 the Federal Network Agency started to launch yearly tenders for sites in the North Sea and Baltic Sea which are conducted in cooperation with the Federal Maritime and Hydrographic Agency (BSH) according to the Wind Energy Act (WindSeeG). The German Meteorological Service (DWD) supports the BSH in compiling the required wind information. This information is made publicly available by the BSH to bidders via the PINTA portal (https://pinta.bsh.de) as part of the tendering procedures.</p><p>Detailed information on the wind conditions on the sites is crucial for the bidders' bid calculations. This information is compiled in collaboration by the BSH and the DWD with the participation of external contractors. In detail, these are in-situ measurements on the research platforms in the North Sea and Baltic Sea, FINO1, FINO2 and FINO3 (https://www.fino-offshore.de/de/index.html). Furthermore, this comprises one-year LiDAR measurements are carried out by external contractors on behalf of the BSH at the sites to be tendered, as well as data and evaluation results of the COSMO-REA6 and ERA5 reanalyses are provided by the DWD. These data sets are the basis for the preparation of summarised overall reports on the wind conditions on the sites.</p><p>The reanalysis and measurement data provided allow a detailed investigation of the seasonal variability as well as an in-depth assessment of the current as well as the historical wind field on each site. The focus of the measurements is on the heights relevant for future wind turbine types, i.e. in the range of 40 to 200 metres. The evaluation of the reanalyses is carried out for the grid points closest to the areas as well as the surrounding grid points and is validated using the existing measurement data. Previous evaluations show a very good correlation, which gives the reanalyses a high significance to determine the wind conditions on the sites. In addition, information on interannual variability is required. Long-term time series of geostrophic wind derived from air pressure data from coastal stations enable an assessment of multi-decadal variations.</p>
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