EDITORIAL SYNOPSIS These investigations demonstrate the dependence of gastrointestinal function on pituitary gland secretions. Hypophysectomy decreased all indices of gastric secretion in the dog but these could be restored either by cortisone or growth hormone. No histological changes were found.The dependence of gastric mucosal structure and function on hormonal activity has been the subject of many investigations (Welbourn and Ward, 1962;Zollinger and Craig, 1960;Grossman, 1950). The conflicting nature of experimental findings and interpretations, particularly as related to the effect of adrenal cortical hormones on gastric secretion, is reflected in many articles reviewing this subject

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