The aerial parts of Аrtemisia annua L. were collected from Varzob, Rudaki, and Hisor regions of Tajikistan. The essential oil was obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry. The essential oils of aerial parts of А. annua were dominated by the monoterpenoids like camphor (32.5%-58.9%), 1,8-cineole (13.7%-17.8%), camphene (4.5%-8.4%), and α-pinene (1.9%-7.3%). Hierarchical cluster analysis of A. annua essential oils indicated the existence of 3 A. annua chemotypes: camphor/1,8-cineole, camphor, and artemisia ketone. The essential oils of А. annua show weak antioxidant activity and average antibacterial activity. In our opinion, the antibacterial activity of А. annua essential oils is related to the presence of 1,8-cineole. To our best knowledge, this is the first report concerning the chemical composition, chemotypic variation, antioxidant, and antimicrobial activities of the essential oils obtained from the aerial parts of А. annua, growing wild in Tajikistan.
Fused pyrimidine derivatives R 0515Synthesis and Antimicrobial Activity of 2-Bromo-7-methyl-5-oxo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidine. -The title compound (III) shows a wide spectrum of antimicrobial activity on the level of oxytetracyclin hydrochloride. -(SALIMOV, T. M.; KUKANIEV, M. A.; SATTOROV, I. T.; OSIMOV, D. M.; Khim.-Farm. Zh. 39 (2005) 6, 28-29; Tajik Vet. Res. Inst., Acad. Agric. Sci., Dushanbe 734005, Tajikistan; Russ., Abstr. Eng.) -Y. Steudel 43-175
The synthesis of 2-bromo-7-methyl-5-oxo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidine is described. This compound exhibits a broad spectrum of antimicrobial action and can be useful in the search for new antimicrobial drugs.
A series of thiuronium salts have been synthesized via reactions of various thioamides with 2-bromo-7-methyl-5-oxo-5H-1,3,4-thiazolo[3,2-a]pyrimidine. The products have been characterized with respect to antimicrobial activity. 421 0091-150X/06/4008-0421
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