Reed Hartman Highway, C i n c i n n a t i , Ohio 45241 Ditallow Dimethyl Ammonium Chloride; CAS161789-80-8; Quaternary ammonium compounds, bis(hydrogenated t a l l o w a l k y l ) dimethyl, c h l o r i d e s ; Adogen 448; DTDMAC Compound Tested: Dose Preparation: 202 W/V aqueous Test and Results: Eye I r r i t a t i o n 1 Protocol B r i e f : The test s o l u t i o n w a s administered a t a dose of 0.1 ml t o t h e c o n j u n c t i v a l sac of one eye i n 3 a l b i n o r a b b i t s . The material w a s n o t r i n s e d . Readings were taken a t 1 hour and days 1, 2, 3, 4 and 7. Results: The Maximum Average Score w a s 9.33 on day 1. Only i r r i t a t i o n t o t h e conjunctiva was observed which c l e a r e d by day 7. 'Drake, J . H . , Woodard, G. and Calvery, H.O. (1944). Methods f o r t h e study of i r r i t a t i o n and t o x i c i t y of substances a p p l i e d t o p i c a l l y t o t h e s k i n and mucous membranes. J o u r n a l of Pharmacology and Experimental T h e r a p e u t i c s , 82; 377-390, 1944.
Die Amminchloride (I) und (II) sowie das durch Zers. an der Luft gemäß Reaktion A aus (I) entstehende Chloridhydroxid (III) kristallisieren in den Raumgruppen Pnma, Abm2 bzw. P63mc mit Z=4, 4 bzw. 2. Im Octaammin (I) ist die Umgebung des Ca ein verzerrtes triangulares (NH3 )6‐Prisma und im Diammin (II) ein etwas unregelmäßiges Cl4(NH3)2‐Oktaeder.
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